BACKGROUND: The effects of celiac disease (CeD) on physical well-being and quality of life during the pregnancy and postpartum (pp) period are not well-known. METHODS: Prospective study of pregnant women with biopsy-confirmed CeD, following a gluten-free diet (GFD). After completing a general clinical questionnaire about CeD history, subjects received a series of surveys per pregnancy trimester, shortly after their delivery, and at 1, 3 and 6 months pp. It included a symptom questionnaire, the Flanagan Quality of Life Scale (QOLS), the CeD GSRS, GF-EAT, CDAT, ICDSQ and SF-36. Target enrollment is 30 subjects with CeD. RESULTS: 13 women with CeD have been enrolled so far, mean age 33.6 (SD 3.8) yo, on a GFD for 9.1(SD 5.2) years and 28.5(SD 8.2) weeks pregnant at the time of inclusion. Low birth weight was the only complication reported(n=1). Participants could differentiate CeD associated symptoms and general symptoms throughout their pregnancy and afterwards, with most common CeD related symptoms being bloating(n=6), diarrhea(n=5) and constipation (n=5). Mean CeD GSRS scores were 19.1 during pregnancy and 18.8 during pp (mild symptoms burden). GFD adherence assessed by GF-EAT and CDAT were very good (mean CDAT 11 and 11.4). 7/13 women reported possible rare accidental gluten exposures but were mostly unsure about the exposure. Mean ICDSQ scores were low, without changes during the pp (0.20 and 0.16, respectively). QOLS was slightly below the standard for healthy adults at 88 and 84 during pregnancy and pp respectively, but increased to 90 at 6-month pp. Finally, SF-36 was similar to general population, except for the energy fatigue domain (pregnancy: 48.1, pp: 46.5). CONCLUSIONS: This interim analysis suggests general stability of GI symptoms related to CeD and low impact of symptoms on quality of life during the peripartum period among women with longstanding CeD adherent to a GFD.